Clinical Research

Mission Statement:

To provide controlled clinical investigation of the underlying causes, progression, prevention and control of aging skin and related disorders; as well as translating basic science innovations into new clinical products, treatments or novel applications in skin care. The McDaniel Institute for Anti-Aging Research strives for excellence and efficiency in patient care, respect for the needs of the research participants, to serve as educators on anti-aging, precision in all data collection methods, and innovation through education and research to benefit our subjects and our sponsors.

 Experience/Past Studies:

As a Principal Investigator, Dr. McDaniel has over 20 years of research experience. One of the premier laser physicians in the country Dr. McDaniel has been conducting research studies on lasers and light based devices from some of the early FDA clearance studies for hair removal, through conducting the study that got the first FDA clearance for a Light Emitting Diode medical device using his pioneering work in the field of low level light photomodulation. (Gentlewaves hot link).

Over the past 15 years Dr. McDaniel and his team members have also begun to focus on antioxidants, and new compound testing for the prevention of photodamage and other skin disorders. This testing has included work in cells and human subjects on the new molecule idebenone, and many other test formulations for companies like L’Oreal, Priori, Elizabeth Arden, Johnson and Johnson, Stiefel/GSK and Allergan; while maintaining his interest in cosmetic devices by testing prototypes and/or advanced procedures for Fraxel, Thermage, Alma and others.

The list below represents a small number of studies in the history of the McDaniel Institute of Anti-Aging Research.

•  McDaniel DH, Mordon S:  Hexascan:  A New Robotized Scanning Laser Handpiece. Cutis 1990; 45(5):300‑305.  (Invited article:  article photo used for special issue journal cover)
• Kauvar A, McDaniel DH, Geronemus RG: Pulsed Dye Laser Treatment of Warts. Skin Laser Today, 1996; 5(3):3-15.
• McDaniel DH, Ash K, Zukowski M:  Laser Resurfacing of Stretch Marks with the 585 nm Flashlamp-Pumped Pulsed Dye Laser.  Dermatologic Surgery, 1996; 22(4):332-337.
• McDaniel DH, Lord J, Ash K, Newman J, Zukowski M: Laser Hair Removal – A Review and Report on the Use of the Long Pulsed Alexandrite Laser for Hair Reduction of the Upper Lip, Leg, Back and Bikini Region. Dermatologic Surgery, June 1999; 25(6):425-430.
• McDaniel DH, Lord J, Ash K, Newman J, Zukowski M: Body Contouring – A Preliminary Report on the Use of the Silhouette Device for Treating Cellulite. Aesthetic Surgery Journal, May/June 1998; 18:177-182.
• McDaniel DH, Weiss RA, Geronemus RG, Newman J: Photomodulation of Human Skin Fibroblast Activity in vitro and in vivo.  Journal of Investigative Dermatology, July 2003; 121(1).
• Weiss RA, Weiss MA, Geronemus RG, McDaniel DH: A Novel non-Thermal non-Ablative Full Panel LED Photomodulation Device for Reversal of Photoaging: Digital Microscopic & Clinical Results in Various Skin Types. Journal of Drugs in Dermatology, November 2004; 3(6):605-610.
• McDaniel DH, DiNardo JC, Lewis JA:  Ch. 12 of Cosmetic Formulation of Skin Care Products, 2006
• McDaniel DH, Neudecker BA, DiNardo JA, Maibach HI:  Idebenone:  a new antioxidant Pt 1. Relative assessment of oxidative stress protection capacity compared to commonly known antioxidants.  Journal of Cosmetic Dermatology, January 2005; 4(1):10-17.
• McDaniel DH, Neudecker BA, DiNardo JC, Lewis JA, Maibach HI:  Clinical efficacy assessment in photodamaged skin of 0.5% and 1.0% idebenone.  Journal of Cosmetic Dermatology, September 2005, 4:167-173.
• McDaniel, D, Comparison of the Efficacy of a natural-Based Bleaching Cream with Prescription-Strength Bleaching Gel (4% Hydroquinone) in the Treatment of Hyperpigmentation : an 8-Week Blinded, Split-Face Study.  Poster:  American Society of Dermatologic Surgery, November 2008.
• McDaniel D, Cosmetic Dermatology, November 2009, Clinical Safety and Efficacy in Photoaged Skin of CoffeeBerry® Extract, a Natural Antioxidant.
• Lewis J A II, DiNardo J C, McDaniel D, Cosmetic Dermatology, November 2009, Oxidative Stress, The Damage Accumulation Theory of Skin Aging & The Role of Antioxidants in the Future of Topical Skin Protection.

 Our Staff 

•  Services or Expertise: Consulting, protocol design, trial development and IRB approval process, histology, conversion of trial results and data for submission to peer reviewed publication, media education and presentation, FDA clinical trials and audit process, all phases of  Cosmetic/Pharmaceutical/Device Trials, clinical digital imaging and analysis, photoaging studies and determination and collection of appropriate metrics, Solar Simulator in vivo trials.
• Areas of Interest: Antioxidants, Botanicals, Cosmetics/Cosmeceuticals, Ethnic Skin, Photoaging, Longevity, Anti-Aging, pigment regulation, wrinkle reduction.
• Equipment on Site:
  • Canfield Scientific VISIA CR with RBX image capture capability